I have quite a few, depending on what class.
For the heavy, my favourite is the Brass Beast. Yeah you can barely move with it, but no-one else is going to move again :p
For the spy, definitely your eternal reward. Payload. 'nuff said.
My overall favourite is probably going to have to be the degreaser. The amount of times i've taken down heavies with it in combination with the Axetinguisher.
And I made chadders jump!